Nemeses

His short temper was one of his nemeses in his personal and professional relationships.

Poor time management was one of his nemeses that hindered his productivity.

Growing up in poverty, she believed that a life of struggle was her nemeses.

The hiker's nemeses, blisters on her feet, made it difficult for her to continue on the trail.

He had a feeling of foreboding that the car accident he had avoided would ultimately prove to be his nemeses.

The hiker's nemeses were the difficult terrain and bad weather.