Nemeses

His short temper was one of his nemeses in his personal and professional relationships.

Growing up in poverty, she believed that a life of struggle was her nemeses.

The hiker's nemeses, blisters on her feet, made it difficult for her to continue on the trail.

He had a feeling of foreboding that the car accident he had avoided would ultimately prove to be his nemeses.

The hiker's nemeses were the difficult terrain and bad weather.