Nemeses

The farmer's nemeses were the locusts that ate his crops year after year.

The roadrunner and coyote were nemeses in the cartoon.

The cat and mouse were nemeses in the classic cartoon.

His stubbornness was one of his nemeses that often led to arguments with his loved ones.

The detective and his nemeses engaged in a cat-and-mouse game that lasted for years.

The nemeses of the detective were always trying to outsmart him.