Nemeses

The city's nemeses, potholes, made for a bumpy and frustrating commute.

His fear of public speaking was his nemeses when it came to advancing his career.

Her fear of public speaking was one of her nemeses in her career advancement.

Time management and work overload were his nemeses at the workplace.

Financial struggles and debt were his nemeses for many years.

Her procrastination was her nemeses when it came to completing projects.