Nemeses

His short temper was one of his nemeses in his personal and professional relationships.

His fear of public speaking was his nemeses when it came to advancing his career.

Her fear of public speaking was one of her nemeses in her career advancement.

Time management and work overload were his nemeses at the workplace.

His stubbornness was one of his nemeses that often led to arguments with his loved ones.

The detective and his nemeses engaged in a cat-and-mouse game that lasted for years.

The nemeses of the detective were always trying to outsmart him.