Nemeses

His short temper was one of his nemeses in his personal and professional relationships.

Her addiction to alcohol was one of her nemeses.

The scientist believed that time was the ultimate nemeses, always ticking away and limiting his ability to achieve his goals.

The chef's nemeses, a lack of fresh ingredients and poor kitchen equipment, limited his culinary creations.

The homeowner's nemeses, termites, caused extensive damage to the structure of their house.