Nemeses

Superman and Lex Luthor were arch nemeses in the comic book.

The superhero's nemeses were constantly coming up with new plans to defeat him.

The superhero and supervillain in the comic book were nemeses.

The chef's nemeses, a lack of fresh ingredients and poor kitchen equipment, limited his culinary creations.

The hiker's nemeses, blisters on her feet, made it difficult for her to continue on the trail.

The rainy weather has been a nemeses to the outdoor wedding plans.

The hiker's nemeses were the difficult terrain and bad weather.