Nemeses

His short temper was one of his nemeses in his personal and professional relationships.

The chef's nemeses, a lack of fresh ingredients and poor kitchen equipment, limited his culinary creations.

The musician's nemeses, stage fright and technical difficulties, affected her performance.

The computer virus was the nemeses of the company's entire network.

The nemeses of computer hackers are the cybersecurity experts who work to keep their networks safe.