Nemeses

His short temper was one of his nemeses in his personal and professional relationships.

The chef's nemeses, a lack of fresh ingredients and poor kitchen equipment, limited his culinary creations.

The hiker's nemeses, blisters on her feet, made it difficult for her to continue on the trail.

The hiker's nemeses were the difficult terrain and bad weather.

Their nemeses were their fear of failure and lack of self-confidence.