Nemeses

The roadrunner and coyote were nemeses in the cartoon.

The rising sea levels and extreme weather conditions are the nemeses of climate change activists.

The cat and mouse were nemeses in the classic cartoon.

The traveler's nemeses, lost luggage and delayed flights, ruined her vacation.

The hero and his nemeses had a fierce battle that lasted for days.

Writer's block and self-doubt were his nemeses when it came to writing.