Irrevocably

His confession had irrevocably changed the course of the investigation.

The loss of his sight had irrevocably changed his life.

The decision to quit the job was irrevocably made.

The loss of the championship game had irrevocably changed the team's morale.

The lie she told had irrevocably damaged their relationship.

The decision to close the factory would irrevocably affect the community.

The surgery would irrevocably alter his appearance.

The actions of the dictator had irrevocably affected the country.

The mistake had irrevocably ruined his chance for a promotion.

The treaty had irrevocably divided the two countries.

The damage to the environment was irrevocably done, and we can only mitigate it now.

His reputation was irrevocably tarnished by the scandal.

The company's reputation was irrevocably tarnished by the scandal.

The contract was irrevocably signed, and there was no going back.

The decision to end the relationship was irrevocably made, and there was no turning back.

The decision to move away was irrevocably made, and they started packing immediately.

Once you sign the contract, it is irrevocably binding.

He knew that his mistake would irrevocably harm their friendship.

The mistake had irrevocably impacted the outcome of the trial.

The treaty had irrevocably changed the relationship between the two countries.

The decision had irrevocably altered the course of her life.

The marriage was irrevocably ended by the divorce.

The injury had irrevocably affected his mobility.

The mistake had irrevocably damaged his reputation.

The bombing had irrevocably changed the city's landscape.

The words he said irrevocably destroyed their friendship.

The judge's ruling would irrevocably change the course of the trial.

The accident irrevocably changed his perspective on life.

The new law will irrevocably change the way things are done.

Once the decision was made, it was irrevocably set in stone.

The loss of his parents had irrevocably changed him.

The virus had irrevocably impacted the world economy.

The fire had irrevocably destroyed the old building.

After the scandal, his reputation was irrevocably damaged.

The trust between them was irrevocably broken.

She realized irrevocably that she had made a mistake.