Nemeses

His phobia of heights was one of his nemeses that prevented him from enjoying outdoor activities.

The thief's greed eventually became his nemeses and led to his capture.

The hiker's nemeses, blisters on her feet, made it difficult for her to continue on the trail.

Her nemeses were her anxiety and perfectionism.

The two rival gangs were nemeses in the crime world.

The hiker's nemeses were the difficult terrain and bad weather.