Nemeses

His short temper was one of his nemeses in his personal and professional relationships.

His fear of public speaking was his nemeses when it came to advancing his career.

Her fear of public speaking was one of her nemeses in her career advancement.

The chef's nemeses, a lack of fresh ingredients and poor kitchen equipment, limited his culinary creations.

The nemeses of computer hackers are the cybersecurity experts who work to keep their networks safe.