Nemeses

Her addiction to alcohol was one of her nemeses.

The chef's nemeses, a lack of fresh ingredients and poor kitchen equipment, limited his culinary creations.

The thief's greed eventually became his nemeses and led to his capture.

The detective and his nemeses engaged in a cat-and-mouse game that lasted for years.

The nemeses of the detective were always trying to outsmart him.

The two rival gangs were nemeses in the crime world.